An old Parkinson's drug eased the inability to feel pleasure in depression by 4 points on a standard scale, versus placebo
In a placebo-controlled trial of 82 adults with anhedonic depression, the dopamine drug pramipexole cut pleasure-scale scores 4.04 points more than placebo over 9 weeks.
Peer-reviewed · Nature Medicine · n=82 · 19 June 2026